Readers may be interested in a similar analysis that we conducted2 among 569 middle-class African-American and white children residing in a geographically defined suburban area of Detroit, MI. These children, who were between the ages of 6 and 8 years, were invited to undergo a clinical evaluation, including the measurement of specific IgE levels and the performance of skin-prick tests. The skin-prick tests were performed by using commercial extracts of Dermatophagoides farinae, Dermatophagoides pteronyssinus, cat, dog, Alternaria, short ragweed, and bluegrass, in addition to saline solution and histamine solution (1 mg/mL), which acted as positive and negative controls, respectively. A positive skin test result was defined as one with a sum of perpendicular wheal diameters of > 4 mm with a larger surrounding flare. Allergen-specific serum IgE concentrations were measured using the commercially available assays to the allergens listed above, along with a sample of children who also were tested for cockroach. A specific IgE concentration of > 0.35 IU/mL was considered to be evidence of a detectable antibody.