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Occupational and Environmental Lung Disease |

Clinical Correlation of Asbestos Bodies in BAL Fluid*

Pratan Vathesatogkit, MD; Timothy J. Harkin, MD, FCCP; Doreen J. Addrizzo-Harris, MD, FCCP; Marion Bodkin, MS; Michael Crane, MD; William N. Rom, MD, MPH, FCCP
Author and Funding Information

*From Bellevue Hospital Chest Service (Drs. Vathesatogkit, Harkin, Addrizzo-Harris, Rom, and Ms. Bodkin), Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York; and Consolidated Edison (Dr. Crane), New York, NY.

Correspondence to: William N. Rom, MD, MPH, FCCP, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, Bellevue Hospital, NB 7N24, 550 First Avenue, New York, NY 10016; e-mail: william.rom@med.nyu.edu



Chest. 2004;126(3):966-971. doi:10.1378/chest.126.3.966
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Background: Asbestos bodies (AB) in BAL cells are specific markers of asbestos exposure.

Methods: We retrospectively reviewed BAL cytocentrifuge slides of 30 utility workers with a history of asbestos exposure and 30 normal volunteers. BAL cytocentrifuge slides were blinded and scanned under 40 × light microscope.

Results: AB were found more frequently in subjects with a history of asbestos exposure compared to normal volunteers (10 of 30 subjects, 33%, vs 0 of 30 subjects). The mean number of AB seen in the AB-positive group was 2.7 per slide. Demographic data were comparable including age, gender, and smoking. Exposure histories were also similar: duration > 20 years, onset > 30 years ago, and time since last exposure > 7 years. More AB-positive patients reported respiratory symptoms (70% vs 26%, p < 0.05). High-resolution CT scans of AB-positive patients revealed a higher prevalence of parenchymal disease (70% vs 26%, p < 0.05). AB-positive subjects had reduced pulmonary function compared to AB-negative subjects: FVC (86% vs 97% predicted), FEV1 (77% vs 92% predicted, p < 0.05), and diffusion capacity of the lung for carbon monoxide (76% vs 104% predicted, p < 0.01).

Conclusion: In individuals with a history of asbestos exposure, the presence of AB in BAL cells is associated with higher prevalence of parenchymal abnormalities, respiratory symptoms, and reduced pulmonary function.

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