0
Opinions/Hypotheses |

Can Low-Molecular-Weight Heparin Improve the Outcome of Patients With Operable Non-Small Cell Lung Cancer? : An Urgent Call for Research

Marco Alifano, MD; Giovanni Benedetti, MD; Rocco Trisolini, MD
Author and Funding Information

*From the Units of Thoracic Surgery (Dr. Alifano), Medical Oncology (Dr. Benedetti), and Thoracic Endoscopy (Dr. Trisolini), Maggiore-Bellaria Hospital, Bologna, Italy.

Correspondence to: Marco Alifano, MD, Chirurgia Toracica, Ospedale Maggiore, Largo B. Nigrisoli 2, 40100 Bologna, Italy; e-mail: marcoalifano@yahoo.com



Chest. 2004;126(2):601-607. doi:10.1378/chest.126.2.601
Text Size: A A A
Published online

Extract

Non-small cell lung cancer (NSCLC) represents a major public health problem worldwide. In western countries, lung cancer deaths range from 5 to 27/100,000 in women to 25 to 77/100,000 in men, and its incidence is thought to be very close because of the high case-fatality rate of the disease.12

As far as treatment is concerned, surgery represents the mainstay in stages I-II, and in some subsets of patients with stage IIIA (ie, patients with minimal N2 or T3N1 disease). Stage IIIA, however, includes an heterogeneous group of patients who are usually offered a multimodal approach including surgery and/or chemotherapy and/or radiotherapy. The 5-year survival rates after surgery are satisfactory only in pT1N0 disease, with figures of approximately 70 to 90%,36 whereas they fall in more advanced stages: values of 57%, 55%, 39%, and 38% have been reported in T2N0, T1N1, T2N1, and T3N0 disease, respectively.3 In stages IIIA-B, the survival rate is even lower in spite of aggressive treatments.3,711

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
Treatment and Prevention of Heparin-Induced Thrombocytopenia*: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
Parenteral Anticoagulants*: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
PubMed Articles
Guidelines
Guidelines on the use and monitoring of heparin.
British Committee for Standards in Haematology | 9/25/2009
Venous thromboembolism (VTE).
University of Michigan Health System | 7/31/2009
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543