0
Editorials |

Dutch Hypothesis : Revisited?

S.K. Jindal, MD, FCCP
Author and Funding Information

Affiliations: Chandigarh, India
 ,  Dr. Jindal is Professor and Head of Pulmonary and Critical Care Medicine, Postgraduate Institute of Medical Education and Research.

Correspondence to: S.K. Jindal, MD, FCCP, Professor and Head, Department of Pulmonary Medicine, Postgraduate Institute of Medical, Education & Research, Chandigarh, India



Chest. 2004;126(2):329-331. doi:10.1378/chest.126.2.329
Text Size: A A A
Published online

Extract

Bronchoreversibility in COPD has remained a matter of debate ever since the known association of tobacco smoking with its pathogenesis and progression. What has remained enigmatic is the observation that not all smokers demonstrate a similar susceptibility to the decline in lung function and that bronchoreversibility in COPD patients is demonstrable only in a subgroup of patients. However, it is important to identify this subgroup of patients for making treatment decisions.

It has been proposed1 that smokers with an allergic diathesis have a greater predisposition to develop severe and chronic airflow obstruction, what was popularly known as the “Dutch hypothesis.” Airway narrowing developed in hyperreactive individuals as the primary abnormality as a result of exposure to smoking or other environmental pollutants. This was contrary to the “British hypothesis,” which proposed chronic mucus hypersecretion as a marker of recurrent bronchial infections leading to chronic obstruction of the airways.2 However, the infection hypothesis has been shown to be misconstrued by the findings of several subsequent reports.3 There was no demonstrable relationship shown between exacerbations of infections or their treatment and lung function decline.34

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
Structural Changes in Airway Diseases*: Characteristics, Mechanisms, Consequences, and Pharmacologic Modulation
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543