The article does, however, identify significant predictors of failed PCI in this setting, including the timing of the procedure (≤ 3 days vs ≥ 4 days from presentation with AMI) and the presence of a high thrombus burden in the IRA. The caveat is that several of the predictors of 30-day mortality are similar to the predictors of lack of response to PCI, such as advanced heart failure, diabetes, and multivessel disease. Thus, it is likely that the patients undergoing cardiac catheterization earlier in their presentation are the ones with the highest risk, with consequent worse outcomes for PCI. This point could be further clarified if the details between the time of presentation to the hospital and the time of the catheterization are reported, and if the indications for PCI at ≤ 3 days are identified. Nonetheless, the available information may still be useful when planning for an elective invasive workup of this patient population as it suggests that the optimal timing of PCI after STEMI, when the true “early reperfusion” opportunity has passed, is 4 days after the index event, if there are no clinical reasons to proceed to catheterization sooner.