Cysteinyl leukotrienes are major mediators of inflammation, particularly in asthma and allergic rhinitis. They have potent contractile activity on human bronchi, and also increase microvasculature permeability, mucus secretion, and eosinophil recruitment. LTR-1 and LTR-2 have been localized in bronchial smooth-muscle cells, interstitial macrophages, eosinophils, peripheral monocytes and macrophages, and mast cells. LTR-2 is also present in the heart, brain, and adrenal gland.14 To our knowledge, this is the first report of their presence in human tonsillar tissue. Furthermore, the leukotriene pathway is implicated in association with the inflammatory state of OSAS in children, again for the first time. Given that the regulation of LTRs is poorly understood and that specific receptor antagonists for LTR-2 are not yet available, additional research is warranted to elucidate the significance of these findings. Irrespective, Goldbart et al have unraveled an intriguing putative venue in the pathophysiology of OSAS in children and perhaps also in adults. Whether their observations are confined to the tonsils or could represent a more widespread phenomenon, including CNS involvement, in patients with OSAS is uncertain.