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Nesiritide in Pulmonary Hypertension*

Damian C. Kurian, MD; Ira J. Wagner, MD; Marc Klapholz, MD
Author and Funding Information

*From the Saint Vincent Catholic Medical Centers, New York, NY.

Correspondence to: Marc Klapholz, MD, Chief, Heart Failure Prevention & Treatment Program, Saint Vincent Catholic Medical Centers, 170 West 12th St, Spellman 690, New York, NY 10011; e-mail: mklapholz@svcmcny.org



Chest. 2004;126(1):302-305. doi:10.1378/chest.126.1.302
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We present the case of a patient with severe symptomatic pulmonary hypertension due to rheumatic mitral valve disease who was refractory to traditional therapies, including prostacyclin. Therapy with continuous nesiritide infusion resulted in significant and sustained decreases in pulmonary vascular resistance, an improvement in renal function, and the maintenance of euvolemia.

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