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Bimodality Lung Cancer Screening in High-Risk Patients*: A Preliminary Report

Gregory Loewen, DO, FCCP; Mary Reid, PhD; DongFeng Tan, MD; Donald Klippenstein, MD; Enriqueta Nava, MD; Raj Natarajan; Martin Mahoney, MD, PhD
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*From the Department of Medicine (Dr. Loewen); Department of Cancer Prevention and Population Science (Drs. Reid and Mahoney, and Mr. Natarajan); Department of Pathology (Drs. Tan and Nava); Department of Diagnostic Radiology (Dr. Klippenstein); Roswell Park Cancer Institute, Buffalo, NY.

Correspondence to: Gregory M. Loewen, DO, FCCP, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton St, Buffalo, NY 14263; e-mail: gregory.loewen@roswellpark.org



Chest. 2004;125(5_suppl):163S-164S. doi:10.1378/chest.125.5_suppl.163S-a
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It has been argued that chest radiography and sputum cytology are not adequately sensitive for the detection of early lung cancer.1 Central squamous cell lung cancers are only infrequently detected in low-dose spiral CT (LDSCT) screening studies,24 even when cytology is added to the screening protocol. The introduction of autofluorescence bronchoscopy (AF) highlighted the ability to directly visualize central squamous carcinoma in patients who are at high risk for lung cancer. In a meta-analysis of > 1,000 cases, the sensitivity of AF combined with conventional white light bronchoscopy for detection of preinvasive epithelial neoplasms was 80%.5 We hypothesized that AF combined with low-dose spiral CT (LDSCT) of the chest might be useful a screening strategy for a cohort of high-risk patients.

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