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Lung Cancer Screening Using Low-Dose High-Resolution CT Scanning in a High-Risk Workforce*: 3,500 Nuclear Fuel Workers in Three US States

Albert Miller, MD; Steven Markowitz, MD; Amy Manowitz, MPH; Jeffrey A. Miller, MD
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*From the Center for the Biology of Natural Systems, Queens College, City University of New York, Flushing, NY.

Correspondence to: Albert Miller, MD, Professor of Clinical Medicine, New York Medical College (Valhalla), Saint Vincent Catholic Medical Centers of New York, 88–25 153rd St, Suite 3J, Jamaica, NY 11432; e-mail: almiller@svcmcny.org



Chest. 2004;125(5_suppl):152S-153S. doi:10.1378/chest.125.5_suppl.152S
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Past and present nuclear fuel workers with demonstrated or potential exposure to lung carcinogens (eg, asbestos, radiation, and/or beryllium) have been screened for early lung cancer with a low-dose (LD) mobile CT scanner at three sites in the states of Kentucky, Ohio, and Tennessee. The age the of subjects was ≥ 45 or 50 years, depending on the duration of smoking and/or occupational exposure. Those with evidence of asbestos-related disease or be sensitization were eligible at any age or with any smoking history. Indeterminate nodules on LD CT scans were rescanned using a full-dose (FD) high-resolution technique. Patients with nodules that remained indeterminate were rescanned at 3, 6, 12, and 18 months. Incidence screens were performed 18 months after the initial scan.

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