*From the National Jewish Medical and Research Center (Dr. Silkoff, Ms. Busacker, and Mr. Trudeau), Denver, CO; and the University of Colorado Health Sciences Center (Dr. Franklin and Ms. Jackson), Denver CO.
Correspondence to: Philip E. Silkoff, MD, FCCP, The National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206; e-mail: email@example.com
Sputum dysplasia on light microscopy in subjects with COPD may be related to the degree of airway inflammation, oxidative stress, and bacterial colonization, all of which may lead to DNA damage.
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