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Mechanisms of Lung Cancer Chemoprevention by d-Glucarate*

Zbigniew Walaszek, PhD; Margaret Hanausek, PhD; Maciej Narog, MD; Peter C. Raich, MD; Thomas J. Slaga, PhD
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*From the AMC Cancer Research Center, Denver, CO.

Correspondence to: Zbigniew Walaszek, PhD, AMC Cancer Research Center, 1600 Pierce St, Denver, CO 80214; e-mail: walaszekz@amc.org



Chest. 2004;125(5_suppl):149S-150S. doi:10.1378/chest.125.5_suppl.149S
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Our previous studies have shown that d-glucaro-1,4-lactone and its precursors, such as d-glucarates, detoxify chemical carcinogens that undergo glucuronidation and inhibit chemically induced experimental tumorigenesis, in part, by inhibiting the enzyme β-glucuronidase (βG). We also have demonstrated that reduced blood levels of d-glucaric acid (GA) are characteristic of human cancer patients as well as rodents bearing chemically induced tumors. The long-term goal of this research is to test our overall hypothesis that GA deficiency and/or high βG levels are markers of detoxification system impairment, and that d-glucarate supplementation may reduce the risk of tumor development in individuals deficient in GA.

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