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Non-small Cell Lung Cancer Molecular Profiles Are Associated With Lung Development*

Alain C. Borczuk, MD; Adel M. Assaad, MD; Liqun Q. Wang, MS; Kristin L. Walter, MD; Charles A. Powell, MD
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*From the Columbia University College of Physicians & Surgeons, New York, NY.

Correspondence to: Charles Powell, Assistant Professor of Clinical Medicine, Columbia University College of Physicians & Surgeons, Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine, 630 W 168th St, New York, NY 10032; e-mail: cap6@columbia.edu



Chest. 2004;125(5_suppl):115S-116S. doi:10.1378/chest.125.5_suppl.115S-a
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Current paradigms hold that lung carcinomas arise from a pleuripotent stem cell that is capable of differentiation into one or several histologic cell types. These paradigms suggest that lung tumor cell ontology is determined by the consequences of gene transcriptional activation and/or repression that recapitulates events that are important in embryonic lung development. We examined the relationship of non-small cell lung cancer (NSCLC) gene profiles with lung development.

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