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Gene Expression Patterns, Prognostic and Diagnostic Markers, and Lung Cancer Biology*

Naftali Kaminski, MD; Meir Krupsky, MD
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*From the Dorothy P. & Richard P. Simmons Center for Interstitial Lung Disease (Dr. Kaminski), Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA; and the Institute of Respiratory Medicine and Physiology (Dr. Krupsky), Sheba Medical Center, Sheba, Israel.

Correspondence to: Naftali Kaminski, MD, Dorothy P. & Richard P. Simmons Center for Interstitial Lung Disease, Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, NW 628 MUH, 3459 5th Ave, Pittsburgh, PA 15261; e-mail- kaminskin@upmc.edu



Chest. 2004;125(5_suppl):111S-115S. doi:10.1378/chest.125.5_suppl.111S
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1Parkin, DM (2001) Global cancer statistics in the year 2000.Lancet Oncol2,533-5432Minna, JD, Roth, JA, Gazdar, AF Focus on lung cancer.Cancer Cell2002;1,49-523Bach, PB, Kelley, MJ, Tate, RC, et al Screening for lung cancer: a review of the current literature.Chest2003;123(suppl),72S-82S4Balsara, BR, Testa, JR Chromosomal imbalances in human lung cancer.Oncogene2002;21,6877-68835Alizadeh, AA, Eisen, MB, Davis, RE, et al Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.Nature2000;403,503-5116van ’t Veer, LJ, Dai, H, van de Vijver, MJ, et al Gene expression profiling predicts clinical outcome of breast cancer.Nature2002;415,530-5367Beer, DG, Kardia, SL, Huang, CC, et al Gene-expression profiles predict survival of patients with lung adenocarcinoma.Nat Med2002;8,816-8248Ramaswamy, S, Ross, KN, Lander, ES, et al A molecular signature of metastasis in primary solid tumors.Nat Genet2003;33,49-549Yeoh, EJ, Ross, ME, Shurtleff, SA, et al Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.Cancer Cell2002;1,133-14310Mountain, CF Lung cancer staging classification.Clin Chest Med1993;14,43-5311Sandusky, GE, Mintze, KS, Pratt, SE, et al Expression of multidrug resistance-associated protein 2 (MRP2) in normal human tissues and carcinomas using tissue microarrays.Histopathology2002;41,65-7412Huang, E, Cheng, SH, Dressman, H, et al Gene expression predictors of breast cancer outcomes.Lancet2003;361,1590-159613Garber, ME, Troyanskaya, OG, Schluens, K, et al Diversity of gene expression in adenocarcinoma of the lung.Proc Natl Acad Sci U S A2001;98,13784-1378914Bhattacharjee, A, Richards, WG, Staunton, J, et al Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses.Proc Natl Acad Sci U S A2001;98,13790-1379515Wigle, DA, Jurisica, I, Radulovich, N, et al Molecular profiling of non-small cell lung cancer and correlation with disease-free survival.Cancer Res2002;62,3005-300816Gordon, GJ, Jensen, RV, Hsiao, LL, et al Translation of microarray data into clinically relevant cancer diagnostic tests using gene expression ratios in lung cancer and mesothelioma.Cancer Res2002;62,4963-496717Sugita, M, Geraci, M, Gao, B, et al Combined use of oligonucleotide and tissue microarrays identifies cancer/testis antigens as biomarkers in lung carcinoma.Cancer Res2002;62,3971-397918Welsh, JB, Sapinoso, LM, Kern, SG, et al Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum.Proc Natl Acad Sci U S A2003;100,3410-341519Park, IW, Wistuba, II, Maitra, A, et al Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer.J Natl Cancer Inst1999;91,1863-186820Powell, CA, Spira, A, Derti, A, et al Gene expression in lung adenocarcinomas of smokers and non-smokers.Am J Respir Cell Mol Biol2003;29,157-16221Johnson, SK, Kerr, KM, Chapman, AD, et al Immune cell infiltrates and prognosis in primary carcinoma of the lung.Lung Cancer2000;27,27-3522Moran, CJ, Arenberg, DA, Huang, CC, et al RANTES expression is a predictor of survival in stage I lung adenocarcinoma.Clin Cancer Res2002;8,3803-381223Zuo, F, Kaminski, N, Eugui, E, et al Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans.Proc Natl Acad Sci U S A2002;99,6292-6297

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