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Retrovirus-Induced Lung Cancer*: Mechanisms of Transformation of Alveolar Type II Epithelial Cells

James C. DeMartini, DVM, PhD; Judy A. Platt; Amanda Evans; Dennis R. Voelker; Thomas E. Allen
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*From the Department of Microbiology, Immunology, & Pathology (Drs. DeMartini, Ms. Platt, and Mr. Allen), Colorado State University, Fort Collins, CO; and National Jewish Medical and Research Center (Ms. Evans and Mr. Voelker), Denver, CO.

Correspondence to: James C. DeMartini, DVM, PhD, Department of Microbiology, Immunology, and Pathology, Colorado State University, 1619 Campus Delivery, Fort Collins, CO 80523-1619; e-mail: james.demartini@colostate.edu



Chest. 2004;125(5_suppl):106S-107S. doi:10.1378/chest.125.5_suppl.106S-a
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The jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma, which is the only known example of a retrovirus-induced lung cancer. The finding that the JSRV env gene is sufficient to induce the transformation of murine and avian fibroblast cell lines has led to an investigation of the mechanism by which this gene induces transformation. Reports from this and other laboratories have presented conflicting data regarding the requirement for a known SH2-binding motif, which is found within the transmembrane domain of the JSRV env gene, in cellular transformation. However, these reported events have been observed in fibroblast cell lines of laboratory animals, whereas the predominant cell type transformed in the sheep host is an epithelial cell of the lung, the alveolar type II (ATII) cell.

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