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Serial Analysis of Gene Expression Profiles of Developmental Stages in Non-small Cell Lung Carcinoma*

Calum MacAulay, PhD; Kim Lonergan, PhD; Bryan Chi, BSc; Scott Zuyderduyn, BSc; Jaquie Shein, MSc; Ming Tsao, MD; Jean LeRiche, MD; Steven Jones, PhD; Marco Marra, PhD; Stephen Lam, MD; Wan L. Lam, PhD
Author and Funding Information

*From the Departments of Cancer Imaging (Drs. MacAulay and S. Lam), Cancer Genetics (Drs. Lonergan, Chi, and W.L. Lam), Canada’s Michael Smith Genome Science Centre, BC Cancer Agency (Drs. Zuyderduyn, Shein, Jones, and Marra); Cancer Imaging, BC Cancer Agency (Dr. LeRiche), Vancouver, BC, Canada, and the Ontario Cancer Institute (Dr. Tsao), Princess Margaret Hospital, Toronto, ON, Canada.

Correspondence to: Calum MacAulay, PhD, Head, Cancer Imaging Department, BC Cancer Research Centre/BC Cancer Agency, 601 W 10th Ave, Vancouver, BC, Canada V5Z 1L3; e-mail: cmacaula@bccancer.bc.ca



Chest. 2004;125(5_suppl):97S. doi:10.1378/chest.125.5_suppl.97S
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Identifying genes and pathways that are critical to early lung cancer progression (ie, interepithelial neoplasia) would facilitate early detection, chemoprevention strategies, and intervention.

The objective of this study was to identify such pathways through expression profiling. We constructed multiple serial analysis of gene expression (SAGE) libraries to describe gene expression in normal lung epithelial cells, carcinoma in situ, and invasive squamous cell lung cancer. By comparing these profiles, we have identified the changes that accompany the transitions between these progression stages.

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