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Increased Urinary 8-Isoprostaglandin F2α Is Associated With Lower Plasma Selenium Levels and Lower Vegetable and Fruit Intake in an Asbestos-Exposed Cohort at Risk for Lung Cancer*

E. Brigitte Gottschall, MD, MSPH; Pam Wolfe, MS; Albert D. Haegele, BS; Zongjian Zhu, PhD; Cecile S. Rose, MD, MPH; Tricia Sells, BS; Henry J. Thompson, PhD
Author and Funding Information

*From the National Jewish Medical and Research Center (Drs. Gottschall and Rose and Ms. Sells), Denver, CO; and Colorado State University (Ms. Wolfe, Mr. Haegele, and Drs. Zhu and Thompson), Fort Collins, CO.

Correspondence to: E. Brigitte Gottschall, MD, MSPH, 1400 Jackson St, G215, Denver, CO 80206; e-mail: gottschallb@njc.org



Chest. 2004;125(5_suppl):83S. doi:10.1378/chest.125.5_suppl.83S
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Oxidative damage is a putative mechanism in the pathogenesis of asbestos-related lung diseases, including lung cancer. We previously have shown that the lipid peroxidation product 8-isoprostaglandin F2α (8-EPG) in urine was positively associated with years of asbestos exposure and smoking status in an asbestos-exposed cohort. We analyzed the influence of diet (ie, fruit and vegetable intake) and plasma selenium levels (a marker of selenium status) on urinary 8-EPG levels in this population.

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