Fortunately, the American Physiologic Society has taken on the noble task of publishing compendious “handbooks” that provide a greater wealth of information than most students will ever have the opportunity to enjoy. One book of particular interest to the readers of CHEST is Handbook of Physiology, Section 2: The Cardiovascular System, Volume I: The Heart. This text provides detailed chapters that cover the contractile and conductive functions of the heart. The book begins with a wonderful anatomic chapter featuring a wide array of structural electron microscopic photographs of the cardiac muscle. This is followed by a chapter on myocardial growth, including mathematical methods and a great many figures describing myocyte density, volume, etc, throughout a life span and across gender. Thereafter begin the chapters on molecular physiology, with sections on caveolae and gap junctions, cardiac innervation, and excitation-contraction coupling. Midway through the text are sections on conduction, covering both dynamics of ion channels as well as the behavior of the wavefront through the myocardial tissue. Overall, the depth of information is impressive, yet well communicated and well illustrated.