In part one, the in-depth treatise on primary pulmonary hypertension contrasts with the more focused reviews of other entities, in which the discussions center on the disease as an indication for transplantation. This may account for the seemingly disparate quality of the initial chapters. There is also some redundancy in this part of the book that may be helpful to newcomers to the field but not to the seasoned, already-involved “transplantologist.” The reader will note several excellent chapters that are surely destined to serve as standard references, as they provide important insights into mechanisms of disease or great experiential knowledge. Most notable are those covering pulmonary hypertension, genetics and right ventricular function, explant and transplant pathology, immunologic mechanisms of graft injury, and transplant imaging. Other chapters provide sound advice on the evaluation and management of the transplant patient (eg, those on bronchiectasis, anesthesia and ICU care, and hematology). There is also an excellent discussion of similarities and differences in the practice of lung transplantation across several continents.