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The Clinical Practice of Lung Transplantation in North America

Jim J. Egan
Author and Funding Information

Affiliations: Dublin, Ireland
 ,  Dr. Egan is affiliated with the Advanced Lung Disease and Lung Transplant Program, The Mater Misericordiae Hospital and St Vincents University Hospital, University College Dublin.

Correspondence to: Jim J. Egan MD, Consultant Respiratory Physician, Advanced Lung Disease and Lung Transplant Program, The Mater Misericordiae Hospital, University College Dublin, Eccles St, Dublin 7, Ireland; e-mail: jegan@mater.ie



Chest. 2004;125(4):1183-1184. doi:10.1378/chest.125.4.1183
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Evidence-based medicine is most effectively applied in clinical scenarios, which are complex, expensive, and high-risk. In lung transplantation, applying evidence-based medicine is problematic because it involves diverse phenotypes (emphysema vs cystic fibrosis) and different surgical options (single vs double lung transplantation). Furthermore, irrespective of the frequency of advanced lung disease, lung transplantation is offered only to a select few. Therefore, to obtain evidence in the field of lung transplantation solely based on randomized controlled studies is pragmatically difficult. Alternative data sets may be equally effective in providing insight into clinical practice.1

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