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Clinical Investigations: TUBERCULOSIS |

Comparison of Six Biological Markers for the Diagnosis of Tuberculous Pleuritis*

Akio Hiraki; Keisuke Aoe; Ryosuke Eda; Tadashi Maeda; Tomoyuki Murakami; Kazuro Sugi; Hiroyasu Takeyama
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*From the Departments of Respiratory Medicine (Drs. Hiraki, Aoe, Eda, Maeda, and Takeyama) and Clinical Research (Drs. Murakami and Sugi), National Sanyo Hospital, Respiratory Disease Center, Yamaguchi, Japan.

Correspondence to: Keisuke Aoe, MD, PhD, Department of Respiratory Medicine and Clinical Research, National Sanyo Hospital, Respiratory Disease Center, 685 Higashi-kiwa, Ube, Yamaguchi 755-0241, Japan; e-mail: keisukeaoe@mtf.biglobe.ne.jp



Chest. 2004;125(3):987-989. doi:10.1378/chest.125.3.987
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Study objective: We sought a marker to differentiate tuberculous pleural effusions from nontuberculous pleural effusions, which otherwise can be difficult.

Patients: We studied 55 patients with pleural effusions, 20 (36%) with tuberculous pleuritis and 35 (64%) with a nontuberculous etiology.

Measurement and results: Pleural fluid levels of adenosine deaminase, interferon (INF)-γ, interleukin (IL)-12p40, IL-18, immunosuppressive acidic protein, and soluble IL-2 receptors were measured and were subjected to receiver operating characteristic analysis. INF-γ had the greatest sensitivity and specificity for tuberculous pleuritis among the six biological markers studied.

Conclusion: The determination of INF-γ levels in pleural fluid is the most informative in the diagnosis of tuberculous effusion.

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