0
Clinical Investigations: NUCLEAR MEDICINE |

Evaluation of Pleural Disease With 18-Fluorodeoxyglucose Positron Emission Tomography Imaging*

Bernard Duysinx; Delphine Nguyen; Renaud Louis; Didier Cataldo; Tarik Belhocine; Pierre Bartsch; Thierry Bury
Author and Funding Information

*From the Departments of Pulmonary Medicine (Drs. Duysinx, Nguyen, Louis, Cataldo, Bartsch, and Bury) and Nuclear Medicine (Dr. Belhocine), CHU, Liège, Belgium. Dr. Cataldo is a postdoctoral researcher from the Belgian National Fund for Scientific Research (FNRS), Belgium.

Correspondence to: Bernard Duysinx, MD, Department of Pulmonary Medicine, CHU Sart Tilman B35, B-4000 Liège, Belgium; e-mail: bduysinx@swing.be



Chest. 2004;125(2):489-493. doi:10.1378/chest.125.2.489
Text Size: A A A
Published online

Study objectives: To study the ability of positron emission tomography (PET) using 18-fluorodeoxyglucose (FDG) to distinguish between benign and malignant disease in exudative pleural effusions and pleural thickening.

Design: Prospective study of 98 consecutive patients presenting with either pleural thickening or an exudative pleural effusion.

Setting: Department of pulmonary medicine of a university hospital.

Methods: FDG-PET was performed on each subject before invasive procedures were used to determine the etiologic diagnosis. FDG-PET data were analyzed by visual interpretation.

Results: Sixty-three of 98 patients were found to have malignant pleural disease after histologic analysis. Sixty-one of 63 patients with histologically confirmed malignant disease showed FDG uptake within the area of pleural thickening. Uptake was graded as intense in 51 cases and moderate in 10 cases. Only two patients with malignant pleural disease did not show increased FDG uptake. FDG-PET imaging showed an absence of FDG uptake, and correctly classified 31 of 35 benign lesions. For the remaining four lesions, intense FDG uptake was seen in one case of parapneumonic effusion, while moderate and localized uptake was observed in one parapneumonic, one tuberculous, and one uremic pleurisy. The sensitivity of the method to identify malignancy was 96.8% with a negative predictive value of 93.9%, while its specificity was 88.5% and its positive predictive value was 93.8%.

Conclusions: Our results suggest that FDG-PET is an effective tool for differentiating between benign and malignant pleural diseases.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
Guidelines
Intermetatarsal neuroma.
Academy of Ambulatory Foot and Ankle Surgery | 1/16/2004
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543