No achievement highlights the striking developments of the past few decades in cystic fibrosis (CF) care more clearly than the tremendous growth of the adult CF population. This demographic shift has created the need for adult-specific CF care programs and protocols. In June 1999, the Cystic Fibrosis Foundation (CFF) convened a consensus conference to discuss the state of adult CF care. This document summarizes the findings of that meeting and incorporates information gathered since the conference convened. The recommendations embodied herein are intended to serve as a template for US adult CF programs and a resource for those wishing to find information specific to adult CF care. In cases in which prior publications sufficiently treat the subject, references are provided. In cases in which insufficient evidence was available to reach consensus, the best consensus opinions are provided. This document is not intended to replace the Clinical Practice Guidelines for Cystic Fibrosis1 but rather to act as an adult-specific complement.