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Interstitial Lung Disease, Fourth Edition FREE TO VIEW

Charles F. Thomas, Jr
Chest. 2004;125(1):357. doi:10.1378/chest.125.1.357
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By Marvin Schwarz and Talmadge King, eds. Hamilton, ON: BC Decker, 2003; 941 pp; $175.00

Interstitial lung diseases are conditions that can be difficult to characterize, diagnose, and treat, and for most pulmonary specialists are the most challenging and demanding of their practice. These disorders can appear solely in the lung, or as either the initial manifestation or a significant component of a multisystem disorder. In addition, many of these diseases are a consequence of specific exposures that the patient encounters either at the workplace, at home, or from medications or dietary supplements. Further, treatment options, until recently, have been limiting and unsatisfactory. Consequently, physicians need a heightened level of astuteness when caring for patients with presumed or established interstitial lung disease. Interstitial Lung Disease, Fourth Edition, published by BC Decker, is a multiauthored comprehensive review of interstitial lung disease presented as a well-organized volume edited by Marvin Schwarz and Talmadge King, and includes an accompanying CD-ROM (compact disk-read only memory) containing the complete text and illustrations of the book in fully searchable PDF (portable document format) files.

Since the third edition of this book, which was published in 1998, numerous advances have been made in understanding the pathogenesis of many aspects of interstitial lung disease. An example is the discovery of several biological mechanisms involved in the pathogenesis of idiopathic pulmonary fibrosis, which has lead to clinical trials that are ongoing or have recently been completed. The current volume is organized into three parts, comprised of 31 chapters, and is authored by internationally respected authorities in interstitial lung disease. There are a number of new chapters, and all of the previous chapters have been revised since the last edition. Part 1 of the book is entitled “Clinical Approaches,” and the introductory chapter gives recommendations for evaluation and diagnosis of interstitial lung disease. This is followed by chapters that discuss anatomy and pathology, physiology, imaging, BAL, interstitial lung disease in the pediatric patient, and the genetic basis of interstitial lung disease. Part 1 is an outstanding introduction to interstitial lung disease, and each chapter appropriately introduces the reader to its specific topic.

The next section of the book, “Basic Mechanisms,” is devoted to the pathogenesis of interstitial lung disease. Seven chapters in this section emphasize the current understanding of the biological processes involved in lung injury and repair. Chapters are devoted to the lung fibroblast, alveolar epithelium, extracellular matrix, cytokine networks, and immunologic features. The final chapter in this section discusses the application of these aspects of basic science to the development of novel approaches to treat lung fibrosis. The sequencing of the human genome has ushered in the era of medical genomics, and many of these chapters include recent information from studies using genomic approaches to understand lung fibrosis.

The final section of the book, “Clinical Entities,” is composed of 18 chapters that describe the clinical manifestations, including radiographic, pathologic features, and management, of specific interstitial lung diseases. Each chapter enables the reader to attain an in-depth comprehension of the disease of interest. New chapters since the last edition include pulmonary Langerhans cell histiocytosis, lymphangioleiomyomatosis, and pulmonary alveolar proteinosis.

Interstitial Lung Disease, Fourth Edition is a comprehensive and well-written volume authored by recognized experts from around the world. The editors of this book should be applauded for compiling an easy-to-read and contemporary text that thoroughly covers these important, and sometimes vexing, disorders.




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