Extracorporeal Life Support is a handbook designed to provide quick reference information for nurses, ECMO specialists, respiratory therapists, perfusionists, and physicians using extracorporeal support. The book is written in an outline format with many tables and figures. The majority of the information is about ECMO, particularly neonatal ECMO, and is described in the context of the spectrum of extracorporeal support and new alternative therapies for cardiopulmonary failure. The text includes brief descriptions of the history of cardiopulmonary bypass and ECMO, and then goes on to present in-depth descriptions of the principles of bypass physiology, including oxygen delivery, gas exchange, and hemodynamic support. In the chapter on the mechanics of ECMO, different types of pumps, oxygenators, and types of ECMO (ie, venovenous and venoarterial) are described. The text includes management guidelines on how to care for the ECMO patient, covering such issues as monitoring, anticoagulation, fluids and electrolytes, nutrition, and sedation. The use of ECMO for different indications (ie, neonatal, pediatric, and adult respiratory failure, and cardiac support) also is covered, and there is a chapter on troubleshooting problems that commonly develop in the ECMO patient. The last two chapters discuss the outcomes of ECMO when it is used in neonatal, pediatric, and adult populations, and newer or emerging therapies for cardiopulmonary failure such as inhaled nitric oxide, high-frequency ventilation, surfactant, intravenous oxygenation and carbon dioxide removal device (IVOX), and perfluorocarbons/liquid ventilation.