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Sputum Peroxynitrite Inhibitory Activity Is Stimulating

Peter G. Tuteur
Author and Funding Information

Affiliations: St. Louis, MO
 ,  Dr. Tuteur is Associate Professor of Medicine, and Director, Pulmonary Function Laboratory, Washington University School of Medicine.

Correspondence to: Peter G. Tuteur, MD, FCCP, Pulmonary and Critical Care Division, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8052, St. Louis, MO 63110; e-mail: tuteurp@msnotes.wustl.edu



Chest. 2003;124(5):1630-1632. doi:10.1378/chest.124.5.1630
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In this issue of CHEST (see page 1755), Kanazawa and colleagues observe that low levels of a biochemical marker in sputum of asthmatics change toward normal in response to the administration of inhaled corticosteroid (beclomethasone dipropionate [BDP]). They extend the observations to demonstrate a strong relationship of structure (albeit biochemical) and airways function. Since these markers presumably reflect inflammation, reversal in the sputum suggests improvement of the intraluminal inflammatory changes of asthma. Superficially, this is a good work. Read the abstract, comment on the connection of asthma to inflammation, and remember sputum peroxynitrite inhibitory activity (PNIA) for rounds tomorrow! But this is not the end of the story.

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