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Clinical Investigations: TRANSPLANTS |

Psychiatric Disorder and Quality of Life in Patients Awaiting Lung Transplantation*

Priti I. Parekh; James A. Blumenthal; Michael A. Babyak; Kari Merrill; Robert M. Carney; R. Duane Davis; Scott M. Palmer; for the INSPIRE Investigators
Author and Funding Information

Affiliations: *From the Departments of Psychiatry and Behavioral Sciences (Drs. Parekh, Blumenthal, Babyak, and Merrill), Surgery (Dr. Davis), and Medicine (Dr. Palmer), Duke University Medical Center, Durham, NC; and Department of Psychiatry (Dr. Carney), Washington University School of Medicine, St. Louis, MO.,  A list of INSPIRE participants is given in the Appendix.

Correspondence to: James A. Blumenthal, PhD, Department of Psychiatry and Behavioral Sciences, Box 3119, Duke University Medical Center, Durham, NC 27710; e-mail: blume003@mc.duke.edu


Affiliations: *From the Departments of Psychiatry and Behavioral Sciences (Drs. Parekh, Blumenthal, Babyak, and Merrill), Surgery (Dr. Davis), and Medicine (Dr. Palmer), Duke University Medical Center, Durham, NC; and Department of Psychiatry (Dr. Carney), Washington University School of Medicine, St. Louis, MO.,  A list of INSPIRE participants is given in the Appendix.


Chest. 2003;124(5):1682-1688. doi:10.1378/chest.124.5.1682
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Published online

Study objective: To examine the relationship between psychiatric comorbidity and quality of life in patients awaiting lung transplantation.

Setting: Duke University Medical Center/Lung Transplantation Program.

Participants: One hundred patients with end-stage pulmonary disease listed for lung transplantation.

Measurements and results: Twenty-five percent (n = 25) of the sample met diagnostic criteria for at least one current mood or anxiety disorder. Controlling for age, gender, ethnicity, percentage of predicted FEV, and lung disease diagnosis, patients with a current psychiatric diagnosis reported poorer general quality of life (p < 0.0001), poorer disease-specific quality of life (p < 0.0001), greater shortness of breath (p = 0.01), more symptoms of psychological distress (p < 0.0001), lower levels of social support (p < 0.0001), and fewer positive health habits (p < 0.04) than their counterparts without a psychiatric diagnosis.

Conclusions: Psychiatric comorbidity affects a significant portion of patients awaiting lung transplantation and is associated with decreased health-related quality of life.


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