0
Articles |

Thrombin*: Can’t Live Without It; Probably Die From It

Kenneth G. Mann, PhD
Author and Funding Information

*From the Department of Biochemistry, University of Vermont College of Medicine, Burlington, VT.

Correspondence to: Kenneth G. Mann, PhD, Department of Biochemistry, 89 Beaumont Ave, Given Building, Room C401, University of Vermont College of Medicine, Burlington, VT 05405; e-mail: Kenneth.Mann@uvm.edu



Chest. 2003;124(3_suppl):1S-3S. doi:10.1378/chest.124.3_suppl.1S
Text Size: A A A
Published online

Extract

Thrombin is a multifaceted protein with a wide range of functions. Walter Seegers, a pioneer in thrombin work, referred to it as “the living enzyme of my blood.”1 The central importance of thrombin in biology, physiology, and pathology is clearly shown by studies conducted with genetically homogenous mice made deficient in components of coagulant pathways essential to thrombin generation and its regulation. Transgenic mice deficient in tissue factor,2 factor VII,3 tissue factor pathway inhibitor,4 factor X,5 factor V,6 prothrombin,7 and protein C8 die in utero or shortly after birth. In contrast, in the outbred human population, deficiencies of coagulation components, essential in mice, yield consequences ranging from mild-to-severe pathology. These observations underscore the complexity of managing the outbred human population with respect to interventions for both thrombosis and hemostasis.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Topics

thrombin

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
New Antithrombotic Drugs*: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)*
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543