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Clinical Investigations: COPD |

Immune Response to Fusobacterium nucleatum and Prevotella intermedia in the Sputum of Patients With Acute Exacerbation of Chronic Bronchitis*

Itzhak Brook; Edith H. Frazier
Author and Funding Information

*From the Naval Medical Center, Bethesda, MD.

Correspondence to: Itzhak Brook, MD, MSc, 4431 Albemarle St NW, Washington DC 20016; e-mail: ib6@georgetown.edu



Chest. 2003;124(3):832-833. doi:10.1378/chest.124.3.832
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Objective: To assess the role of anaerobic bacteria in acute exacerbation of chronic bronchitis (AECB).

Methods: The level of the Ig-A class to two organisms (Fusobacterium nucleatum and Prevotella intermedia) was determined in the sputum of 25 patients with AECB and 25 control patients. The presence and level of these antibodies were investigated by enzyme-linked immunosorbent assay.

Results: The median sputum antibody level for F nucleatum and P intermedia were significantly higher in patients with AECB as compared to control patients (p < 0.05). The IgA levels for F nucleatum was 3.5 times higher in patients with AECB and 3.8 times greater for P intermedia.

Conclusions: This study demonstrates for the first time an elevated sputum antibody titers in patients with AECB to F nucleatum and P intermedia.


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