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Lymphangioleiomyomatosis and SZ α1-Antitrypsin Disease*: A Unique Combination?

Andrew L. Chan; Sunye Kwack; Kirk D. Jones; Marilyn K. Glassberg; Charles R. Gherman
Author and Funding Information

*From the University of California (Drs. Chan and Kwack), Davis Medical Center, Sacramento, CA; University of California (Dr. Jones), San Francisco, CA; University of Miami (Dr. Glassberg), Miami, FL; and Kaiser Permanente Medical Center (Dr. Gherman), San Francisco, CA.

Correspondence to: Andrew Chan, MB, FCCP, 4150 V St, Suite 3400, Sacramento, CA 95817; e-mail: alchan@ucdavis.edu



Chest. 2003;124(2):763-765. doi:10.1378/chest.124.2.763
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We describe a case of a 37-year-old female ex-smoker with lymphangioleiomyomatosis and SZ α1-antitrypsin disease who underwent successful bilateral sequential lung transplantation. While this disease combination has not been described previously, we recommend vigilance for the possibility of such combinations in patients with chronic lung disease. The possible mechanisms of interaction resulting from both disease processes are discussed.

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