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Pegylated Interferon and Ribavirin-Induced Interstitial Pneumonitis With ARDS*

Sandra Abi-Nassif; Eugene J. Mark; Robert B. Fogel; Robert K. Hallisey, Jr
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*From the Department of Pharmacy (Dr. Abi-Nassif and Mr. Hallisey), the Department of Medicine (Dr. Fogel), Division of Pulmonary and Critical Care, and the Department of Pathology (Dr. Mark), Massachusetts General Hospital, Boston, MA.

Correspondence to: Sandra Abi-Nassif, PharmD, Attending Pharmacist, Department of Pharmacy, MGH, Room GRB 005, 55 Fruit St, Boston, MA 02114; e-mail: sabinassif@partners.org



Chest. 2003;124(1):406-410. doi:10.1378/chest.124.1.406
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A 49-year-old man with cirrhosis due to hepatitis C virus developed interstitial pneumonitis documented by surgical lung biopsy specimen evaluation after two weekly doses of pegylated interferon-α2b in combination with ribavirin. He developed ARDS and died after 26 days of hospitalization from multisystem organ failure. This case suggests that interstitial pulmonary disease can occur with pegylated interferon-α2b therapy.

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