A separate section explores treatment approaches based on the pathophysiology of COPD, including therapeutic perspectives on genetics and another on the role of antioxidant therapy. Pharmacologic therapy is covered in seven chapters, and not only deals with individual pharmacologic agents but also carries an innovative description of methodology for therapeutic trials in COPD. In addition to bronchodilators and steroids, the roles of other therapeutic strategies such as vasodilators, analeptics, and mucolytics are covered. Prevention of infection and management of associated conditions including lung cancer, anxiety, and depression and the effect of COPD on sleep are also described. Two chapters deal with the effect of COPD on the heart, an aspect that tends to be overlooked by pulmonologists. A section covering the influence of other factors, including the impact of respiratory muscle performance, nutrition, and physiotherapy, seeks to focus the reader’s attention on facets other than just pharmacology. A section entitled “Instrumental Treatments” includes lucid and well-written reviews of oxygen therapy, noninvasive ventilation, and the role of tracheostomy, but in this case one gets a fleeting impression that there may have been a time lag between writing and publication. A concise account of the role of surgery in COPD is presented and includes worthwhile information on the current state of lung volume reduction surgery and lung transplantation. “Management of the COPD Patients Undergoing Surgery” guides the pulmonologist through the preoperative evaluation as well as postoperative treatment modalities.