Sarcoidosis is a multiorgan disease in which some patients never require therapy and others receive long-term treatment. The prevalence of the disease varies throughout the world. The wide array of rates of disease and clinical outcomes appear related more to the host’s response than to the etiologic agent. Each of us possesses genetic polymorphisms that account for our uniqueness. These polymorphisms influence our risk for acquiring a particular disease, the manifestation of the disease, and the resolution of disease. Sarcoidosis is one of many diseases in which the study of polymorphisms may lead to greater insight regarding disease manifestations.