0
Clinical Investigations: MUSCLES |

Quadriceps Fatigue After Cycle Exercise in Patients With COPD Compared With Healthy Control Subjects*

M. Jeffery Mador; Erkan Bozkanat; Thomas J. Kufel
Author and Funding Information

*From the Division of Pulmonary, Critical Care, and Sleep Medicine (Drs. Mador and Bozkanat), State University of New York at Buffalo, Buffalo, NY; and the Veterans Affairs Western New York Healthcare System (Drs. Mador and Kufel), Buffalo, NY.

Correspondence to: M. Jeffery Mador, MD, Associate Professor of Medicine, Division of Pulmonary, Critical Care, & Sleep Medicine, Section 111S, State University of New York at Buffalo, Veterans Administration Medical Center, 3495 Bailey Ave, Buffalo, NY 14215; e-mail: mador@acsu.buffalo.edu



Chest. 2003;123(4):1104-1111. doi:10.1378/chest.123.4.1104
Text Size: A A A
Published online

Study objectives: Quadriceps fatigue can occur in patients with COPD after exhaustive cycle exercise. The purpose of this study was to determine whether the degree of fatigue elicited by cycle exercise was greater in patients with COPD compared with matched control subjects.

Subjects: Nine male patients with COPD with a mean (± SE) age of 66 ± 3 years and mean FEV1 values of 1.31 ± 0.15 L and 36 ± 5% predicted were compared to nine healthy male subjects with a mean age of 66 ± 2 years.

Methods: Patients with COPD exercised at 60% of peak work capacity until exhaustion. Healthy elderly subjects exercised at a workload that was chosen to produce a similar absolute oxygen uptake (V̇o2) during constant-load exercise as that obtained by the patients with COPD. Quadriceps fatigue was detected by measuring twitch force (unpotentiated twitch force [TwQu] and potentiated twitch force [TwQp]) before and after cycle exercise.

Results: Patients with COPD exercised for a mean duration of 8.4 ± 1.8 min. V̇o2 during exercise was 50 ± 6% of predicted. The healthy elderly control subjects exercised for 10 min, generating a V̇o2 of 48 ± 1% predicted. TwQu fell significantly postexercise in the patients with COPD but not in the matched control subjects. TwQp fell significantly postexercise in both groups, but the fall in TwQp postexercise was significantly greater in the patients with COPD.

Conclusion: For the same absolute V̇o2 and duration of cycle exercise, the amount of fatigue elicited was significantly greater in the patients with COPD compared to age-matched healthy control subjects.

Figures in this Article

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543