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Sildenafil for Pulmonary Arterial Hypertension : Exciting, But Protection Required

Sanjay Mehta
Author and Funding Information

Affiliations: London, ON, Canada
 ,  Dr. Mehta is Associate Professor of Medicine, Vascular Biology Group, Lawson Health Research Institute, London Health Sciences Centre, University of Western Ontario.

Correspondence to: Sanjay Mehta, MD, Division of Respirology, London Health Sciences Center-Victoria South St. Campus, 375 South St, London, ON, Canada; e-mail: sanjay.mehta@lhsc.on.ca



Chest. 2003;123(4):989-992. doi:10.1378/chest.123.4.989
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Pulmonary arterial hypertension (PAH) is a serious, often fatal condition. The clinical hallmarks are progressive breathlessness, exertion limitation, and frequently an inexorable decline to right ventricular (RV) failure and death. Since its initial description > 100 years ago, PAH has remained a difficult and frustrating condition to diagnose and manage for patients and physicians alike. However, based on bedside clinical observation, clinical trials, and basic biological research, we are in a time of great enthusiasm and optimism on both scientific and therapeutic fronts.

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