0
Editorials |

A Model of Human Lung Cancer

Robert J. Lenox
Author and Funding Information

Affiliations: Syracuse, NY
 ,  Dr. Lenox is associated with the Division of Pulmonary and Critical Care Medicine, SUNY Upstate Medical University Hospital.

Correspondence to: Robert J. Lenox, MD, FCCP, Division of Pulmonary and Critical Care Medicine, SUNY Upstate Medical University Hospital, 750 E Adams St, Syracuse, NY 13210



Chest. 2003;123(4):986-987. doi:10.1378/chest.123.4.986
Text Size: A A A
Published online

Extract

Over the last several decades, progress in the treatment of bronchogenic lung cancer has been disappointing. Lung cancer remains the number one cancer killer in the United States. Lung cancer kills more US citizens than colon cancer, breast cancer, and prostate cancer combined.1 Although most cases of lung cancer could be prevented, the treatment of lung cancer is often disappointing.

New modalities, new drugs, and new methods with which to test the utility of new approaches are needed. In the study of infection, laboratory and animal models have proven invaluable. In the study of human cancer, the efficacy of new treatment ideas in various cell lines can be investigated. This provides preliminary useful information, but it does not provide information on the effectiveness of the agent or agents in the prevention of death or metastasis. Such methods also do not provide us with data about toxicity or tissue penetration. These issues can be studied in human subjects, but such studies are expensive, time consuming, and of potential risk to subjects. An animal model of human lung cancer may accelerate the investigation of new treatment ideas. This approach allows a new agent or idea to be used alone or in combination with various other agents, in rapid succession and in a relatively inexpensive manner.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Topics

lung cancer

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543