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Adenosine Airways Responsiveness : What Does It Mean?

Joe W. Ramsdell
Author and Funding Information

Affiliations: San Diego, CA
 ,  Dr. Ramsdell is Professor of Clinical Medicine, University of California, San Diego.

Correspondence to: Joe W. Ramsdell, MD, FCCP, University of California, San Diego, 200 W Arbor Dr, No. 8415, San Diego, CA 92103-8415; e-mail: jramsdell@ucsd.edu



Chest. 2003;123(4):971-973. doi:10.1378/chest.123.4.971
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Extract

The role of adenosine in mediating airway hyperreactivity is an interesting and emerging area of study. Subjects with asthma were noted to have airway hyperresponsiveness to inhaled adenosine in 1983.1 This observation led to a series of clinical and basic investigations that have resulted in our current paradigm for the role of adenosine and adenosine receptors in airways allergic inflammation. This topic has been recently reviewed in detail by Meade et al2 and Polosa et al.3

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