0
Articles |

Asthma and the Human Genome Project: Summary of the 45th Annual Thomas L. Petty Aspen Lung Conference*

Jeffrey M. Drazen, MD, FCCP
Author and Funding Information

*From the Pulmonary Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA.

Correspondence to: Jeffrey M. Drazen, MD, FCCP, Editor-in-Chief, New England Journal of Medicine, 10 Shattuck St, Sixth Floor, Boston, MA 02115; e-mail: hstimpson@nejm.org



Chest. 2003;123(3_suppl):447S-449S. doi:10.1378/chest.123.3_suppl.447S
Text Size: A A A
Published online

Extract

Asthma is at a crossroads. Although the clinical syndrome of asthma has been recognized for millennia, it was research performed in the middle of the last century that established the primary physiologic abnormality as obstruction of the airways to airflow. In addition to airflow obstruction, it was appreciated that the airways of patients were inflamed, that there was hypertrophy and hyperplasia of the mucus secretory apparatus with abnormal amounts of mucus in the airway lumen, and that treatment with adrenergic agonists led to rapid resolution of many of the signs and symptoms of asthma. This latter observation led to the deduction, which still stands, that constriction of the airway smooth muscle was responsible for a substantial proportion of the observed obstruction during an acute asthmatic attack. In the 1970s, as research into the physiology of airflow obstruction reached its peak, investigators began to apply the tools of cell and molecular biology to understanding the root causes of airway obstruction. This resulted in an explosion of new knowledge about the cell and immunobiology of the airway.1 There is now an unprecedented array of potential mechanisms that could lead to the airway obstruction that we recognize as asthma, but there has been little success in sorting out which are the truly active ones. Indeed, it is highly likely that the clinical syndrome of asthma derives from a number of distinct molecular mechanisms. The promise of the future is that the insights derived from the Human Genome Project will provide the keys needed to achieve this distinction at a causal level.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543