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Interleukin-13 and Interferon Modulators of Dendritic Cell Migration in the Lungs*

Janice Hwang, BS; David Yen, BS; Thomas Tschernig, MD; Donna Rennick, PhD; Gabriele Grunig, DVM, PhD
Author and Funding Information

*From the Department of Pathology (Mrs. Hwang and Dr. Grunig), Columbia University, J. P. Mara Center for Respiratory Diseases, St. Luke's-Roosevelt Hospital, New York, NY; DNAX Research Institute for Molecular and Cellular Biology (Mr. Yen and Dr. Rennick), Palo Alto, CA; and Department of Anatomy (Dr. Tschernig), Medical University of Hannover, Germany.

Correspondence to: Gabriele Grunig, DVM, PhD, St. Luke's Roosevelt Hospital, 432 W 58th St, Lab 504, New York, NY 10019; e-mail: gg398@columbia.edu



Chest. 2003;123(3_suppl):439S. doi:10.1378/chest.123.3_suppl.439S
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Mixed T-cell responses characterized by the simultaneous presence of T-helper type 2 and T-helper type 1 cytokines (eg, interleukin [IL]-13 and interferon [IFN]-γ) critically contribute to chronic inflammatory diseases of the lungs, including asthma. We examined the effects of the simultaneous presence of IL-13 and IFN-γ by challenging mice with recombinant cytokines intranasally. Increased numbers of dendritic-like cells accumulated in the airways of mice challenged with IL-13 and IFN-γ. Because immune responses are induced most efficiently in the lymph nodes, we asked if dendritic cells also migrated at increased numbers from the airways to lymph nodes in mice challenged with IL-13 and IFN-γ. Dendritic cells were prepared from the bone marrow, labeled, and transferred into recipient mice by intranasal instillation. Increased numbers of labeled dendritic cells were found in the draining lymph nodes 36 h after transfer in mice challenged with IL-13 and IFN-γ as compared to mice given control protein. These data will be confirmed using dendritic cells made from mice that are transgenic for green fluorescent protein that is expressed in every cell type.

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