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Polymorphisms of the GM-CSF Genes and the Development of Atopic Diseases in At-Risk Children*

Jian-Qing He, MD; Jian Ruan, MD, PhD; Moira Chan-Yeung, MD; Allan B. Becker, MD; Helen Dimich-Ward, MD; Peter D. Paré, MD; Andrew J. Sandford, PhD
Author and Funding Information

*From UBC McDonald Research Laboratories/iCAPTURE Center (Drs. He, Ruan, Paré, and Sanford), St. Paul's Hospital, Vancouver, BC; and Occupational and Environmental Lung Diseases Unit (Drs. Chan-Yeung, Becker, and Dimich-Ward), Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Correspondence to: Jian-Qing He, MD, UBC McDonald Research Laboratories/iCAPTURE Center, St. Paul's Hospital, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; e-mail: jhe@mrl.ubc.ca



Chest. 2003;123(3_suppl):438S. doi:10.1378/chest.123.3_suppl.438S
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Genomic scans have identified a strong linkage of a region on chromosome 5q31 with atopy and atopic diseases in different populations. The GM-CSF gene is located in this region and has been shown to be important in the allergic response. One case-control study showed that the Ile117Thr (3928C/T) polymorphism of the GM-CSF gene is associated with atopic asthma. Our objective was determine the predictive values of polymorphisms in the GM-CSF gene for the development of atopy and atopic diseases.

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