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Pediatric Asthma*: An Approach to Pharmacogenetics Analysis

Stanley J. Szefler, MD
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*From the Divisions of Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO.

Correspondence to: Stanley J. Szefler, MD, National Jewish Medical and Research Center, 1400 Jackson St, Room B121, Denver, CO 80206; e-mail: szeflers@njc.org



Chest. 2003;123(3_suppl):434S-438S. doi:10.1378/chest.123.3_suppl.434S-a
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Numerous studies have clearly demonstrated that inhaled glucocorticoids alleviate clinical symptoms, improve pulmonary function, and reduce airway inflammation; there is some evidence that they may alter disease progression. Current guidelines identify inhaled glucocorticoids as the “preferred” long-term controller asthma medication, especially for moderate and severe persistent asthma.12 Clinical observations suggest that the response to inhaled glucocorticoids is highly dependent on the time of intervention: the earlier used, the more efficacious3; however, it is also clear that the response to inhaled glucocorticoids can vary among patients with some patients being considered “steroid resistant.”4

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