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Provocation With Adenosine 5′-Monophosphate Increases Sputum Eosinophils*

Maarten van den Berge, MD; H.A.M. Kerstjens, PhD; D.M. de Reus; H.F. Kauffman, PhD; G.H. Koëter, PhD; D.S. Postma, PhD
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*From the Departments of Pulmonology (Drs. van den Berge, Kerstjens, Koëter, and Postma) and Allergology (Drs. de Reus and Kauffman), University Hospital Groningen, Groningen, the Netherlands.

Correspondence to: Maarten van den Berge, MD, Department of Pulmonology, University Hospital Groningen, Groningen, the Netherlands; e-mail: m.van.den.berge@int.azg.nl



Chest. 2003;123(3_suppl):417S. doi:10.1378/chest.123.3_suppl.417S-a
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Bronchial hyperresponsiveness is generally assessed by testing with methacholine (MCh) or histamine. Another possible stimulus with which to measure bronchial hyperresponsiveness is adenosine 5′-monophosphate (AMP). We have demonstrated previously1 that the provocative concentration of a substance (ie, AMP) causing a 20% fall in FEV1 (PC20) better reflects airway inflammation in asthma patients than does the MCh PC20. AMP, and by implication adenosine, acts by the release of a variety of inflammatory mediators from mast cells. We intended to assess with the study whether this AMP-induced mediator release initiates an inflammatory process resulting in the recruitment of eosinophils to the airways.

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