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Modulation of Vasodilator-Stimulated Phosphoprotein In Vivo in Human Epithelial Cells by Segmental Allergen Challenge and β2-Agonist Therapy*

Annette T. Hastie, PhD; Vikas Batra, MD; Sandhya Khurana, MD; Kathy A. Carpenter, BS; Rosemary Cirelli, MD; James G. Zangrilli, MD, FCCP; Stephen P. Peters, MD, PhD, FCCP
Author and Funding Information

*From the Thomas Jefferson University, Philadelphia, PA.

Correspondence to: Annette T. Hastie, PhD, Department of Medicine, Thomas Jefferson University, 1025 Walnut St, Room 805, Philadelphia, PA 19107; e-mail: annette.hastie@mail.tju.edu



Chest. 2003;123(3_suppl):377S. doi:10.1378/chest.123.3_suppl.377S
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Extract

The attachment and migration of airway epithelial cells is an important aspect of the repair of antigen-induced inflammatory injury in patients with asthma. Cytoskeletal reorganization is required for the altered attachment and migration of epithelial cells. Vasodilator-stimulated phosphoprotein (VASP) mediates focal adhesion and actin filament binding in a variety of cells and acts as an inhibitor of cell movement. Phosphorylation of VASP via cyclic adenosine monophosphate-dependent and cyclic guanosine monophosphate-dependent protein kinases releases this “brake” on cell motility.

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