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β2-Adrenergic Receptor Polymorphisms in Children With Status Asthmaticus* FREE TO VIEW

Saeed Binaei, BS; Michael Christensen, PhD; Cathy Murphy, RN; Qing Zhang, BS; Michael Quasney, MD, PhD
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*From the Departments of Clinical Pharmacy (Mr. Binaei and Dr. Christensen) and Pediatrics (Mr. Zhang and Dr. Quasney), Children's Foundation Research Center, University of Tennessee, Memphis, TN; LeBonheur Children's Medical Center (Ms. Murphy), Memphis, TN.

Correspondence to: Michael Quasney, MD, PhD, College of Medicine, Department of Pediatrics, 50 North Dunlap, Memphis, TN 38103; e-mail: mquasney@utmem.edu

Chest. 2003;123(3_suppl):375S. doi:10.1378/chest.123.3_suppl.375S
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Genetic polymorphisms within the gene coding for the β2-adrenergic receptor have been identified that influence cell signaling and down-regulation. The Gly/Gly polymorphism at position 16 is associated with increased airway hyperactivity, while the Glu/Glu polymorphism at position 27 is associated with decreased airway hyperactivity. We tested the hypothesis that children with status asthmaticus have genetic polymorphisms that are associated with increased airway hyperactivity.

Blood samples were obtained from children with exacerbations of asthma. Genotypes were determined by polymerase chain reaction amplification and restriction enzyme digestion. Genotypic frequencies were determined and compared with samples from healthy control subjects. Statistical analysis was performed using χ2 analysis.

Thirty-eight children with status asthmaticus were enrolled into the study. The frequencies of the polymorphic sites at amino acid positions 16 and 27 in the β2-adrenergic receptor are shown below. The frequency of the Gly/Gly polymorphism at position 16 was significantly lower in children with status asthmaticus when compared with that of a healthy control group (0.184 vs 0.348, respectively; p < 0.05) [Table 1 ].

Children with status asthmaticus have a lower frequency of the Gly/Gly polymorphism at amino acid position 16 in the β2-adrenergic receptor. Further study is warranted because of the small number of children with asthma who have been evaluated thus far and the wide variety of polymorphisms that may play a role.

Table Graphic Jump Location
Table 1. Frequencies of Polymorphism in the β2-Adrenergic Receptor in Children With Asthma and Control Subjects



Table Graphic Jump Location
Table 1. Frequencies of Polymorphism in the β2-Adrenergic Receptor in Children With Asthma and Control Subjects


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