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Increased Messenger RNA Expression of c-maf and GATA-3 After Segmental Allergen Challenge in Allergic Asthmatics*

Veit J. Erpenbeck, MD; Jens M. Hohlfeld, MD; Marc Discher; Harald Krentel; Andreas Hagenberg; Armin Braun, PhD; Norbert Krug, MD
Author and Funding Information

*From the Fraunhofer Institute of Toxicology and Aerosol Research (Drs. Erpenbeck, Braun, and Krug), Hannover; and Department of Respiratory Medicine (Mr. Discher, Mr. Krentel, and Ms. Hagenberg), Hannover Medical School, Germany.

Correspondence to: Veit J. Erpenbeck, Nikolai-Fuchs-Strasse 1A, Hannover, Germany 30625; e-mail: erpenbeck@ita.fraunhofer.de



Chest. 2003;123(3_suppl):370S-371S. doi:10.1378/chest.123.3_suppl.370S
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Inflammation in allergic asthma is mediated by T-helper type 2 (Th2) cytokines. The expression of these cytokines is dependent on specific and nonspecific transcription factors that bind to regulatory sequences in the promoter. GATA-3 is a Th2-specific transcription factor that belongs to the zinc finger family and binds to the interleukin (IL)-5 promoter. It has also binding sites around the IL-4/IL-13 locus. Another Th2 specific transcription factor is c-maf, which transactivates the IL-4 promoter but does not appear to regulate the expression of other Th2 cytokine genes.

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