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Allergen-Specific Early Neutrophil Infiltration After Allergen Challenge in a Murine Model*

Christian Taube, MD; Azzeddine Dakhama, PhD; Katsuyuki Takeda, MD; Jerry A. Nick, MD; Erwin W. Gelfand, MD
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*From the Departments of Pediatrics (Drs. Taube, Dakhama, Takeda, and Gelfand) and Medicine (Dr. Nick), Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO.

Correspondence to: Erwin W. Gelfand, MD, 1400 Jackson St, Denver, CO 80206; e-mail: gelfande@njc.org



Chest. 2003;123(3_suppl):410S-411S. doi:10.1378/chest.123.3_suppl.410S
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Allergic asthma is characterized by obstruction, hyperresponsiveness, and inflammation of the airways. The inflammatory changes have been described as an accumulation of eosinophils, lymphocytes, and mast cells in the bronchial wall and lumen.1 In the recent past, increased numbers of neutrophils in the airways have been found at different stages of the disease.25 Following allergen challenge in patients with allergic asthma, neutrophils are the first inflammatory cells to accumulate within the airways.68 In murine models, an increase in the numbers of neutrophils following allergen challenge also has been described.9 In this model, mice sensitized to ovalbumin (OVA) received a single intranasal OVA challenge. Interestingly, the initial inflammatory response within the airways was almost exclusively neutrophilic, and this increased number of neutrophils was transient, and was followed later by an influx of eosinophils and lymphocytes, and by the development of airway hyperresponsiveness.9 To date, the mechanisms underlying this early and transient neutrophil inflammation have not been well-defined. The aim of this study was to determine whether this neutrophil influx is (1) allergen-specific and (2) mediated through an Fc receptor and Ig.

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