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Hypothalamic-Pituitary-Adrenal Axis Dysfunction During Sleep in Nocturnal Asthma*

E. Rand Sutherland, MD, FCCP; Monica Kraft, MD, FCCP; M.D. Rex, BS; Misoo C. Ellison, PhD; Richard J. Martin, MD, FCCP
Author and Funding Information

*From the National Jewish Medical and Research Center, Denver, CO.

Correspondence to: R.J. Martin, MD, FCCP, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206; e-mail: martinr@njc.org



Chest. 2003;123(3_suppl):405S. doi:10.1378/chest.123.3_suppl.405S
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Extract

Patients with nocturnal asthma (NA) have increased airway inflammation at night, a phenomenon not seen in patients with non-NA (NNA). We hypothesized that alterations in hypothalamic-pituitary-adrenal axis function may be of importance in the pathogenesis of NA.

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