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Concentration of Cytokines and Growth Factors in BAL Fluid After Allergen Challenge in Asthmatics and Their Effect on α-Smooth Muscle Actin and Collagen III Synthesis by Human Lung Fibroblasts*

Vikas Batra, MD; Sandhya Khurana, MD; Ali I. Musani, MD; Annette T. Hastie, PhD; Katherine A. Carpenter, BS; James G. Zangrilli, MD, FCCP; Stephen P. Peters, MD, PhD, FCCP
Author and Funding Information

From Thomas Jefferson University, Philadelphia, PA.

Correspondence to: Stephen P. Peters, MD, PhD, FCCP, Wake Forest University Health Sciences Center, Center for Human Genomics, Medical Center Blvd, Winston-Salem, NC 27157; e-mail: sppeters@wfubmc.edu



Chest. 2003;123(3_suppl):398S-399S. doi:10.1378/chest.123.3_suppl.398S
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Extract

Asthma is characterized histologically by bronchial subepithelial fibrosis and increased numbers of myofibroblasts. It has been proposed that these myofibroblasts are responsible for the characteristic subepithelial collagen deposition seen in asthma. We hypothesized that the concentration of growth factors and cytokines that is important in asthmatic airway remodeling are elevated in BAL fluid after segmental antigen challenge (SAC). We further hypothesized that these growth factors and cytokines increase α-smooth muscle actin (SMA) and collagen III synthesis by human lung fibroblasts (HLFs).

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