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The Functional Consequences of Structural Changes in the Airways*: Implications for Airway Hyperresponsiveness in Asthma

Lu Wang, MD, PhD; Brent E. McParland, PhD; Peter D. Paré, MD
Author and Funding Information

*From the McDonald Research Laboratories (Drs. McParland and Paré), University of British Columbia McDonald Research Laboratories, iCAPTURE Center, St. Paul’s Hospital, Vancouver, BC, Canada; and the Section of Respiratory Diseases (Dr. Wang), Asthma/COPD Research Centre, Department of Pediatrics, John Buhler Research Centre, University of Manitoba, Winnipeg, MB, Canada.

Correspondence to: Peter D. Paré, MD, McDonald Research Laboratories/the iCAPTURE Center, St. Paul’s Hospital, Burrard Building, 1081 Burrard St, Vancouver, BC, V6Z 1Y6 Canada; e-mail: ppare@mrl.ubc.ca



Chest. 2003;123(3_suppl):356S-362S. doi:10.1378/chest.123.3_suppl.356S
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Over the last decade, there has been increasing recognition that structural change (ie, remodeling) in the airways of asthmatic subjects is a characteristic feature of the disease and may have important functional implications. Remodeling can be defined as changes in the composition, content, and organization of the cellular and molecular constituents of the airway wall.

The recent interest in airway remodeling in asthma patients is highlighted by doing a PubMed search by decade since 1980 using the following key words (Table 1 ): asthma and airway smooth muscle; asthma and inflammation; and asthma and airway remodeling.

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