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Interleukin-4 and Interleukin-13 Augment the Proliferative Effect of Dexamethasone on Distal Lung Fibroblasts*

Christina C. Lewis, PhD; E. Rand Sutherland, MD, FCCP; T.A. Moss; Terri L. Metze, PA RRT; M.D. Rex; Monica Kraft, MD, FCCP
Author and Funding Information

*From the National Jewish Medical and Research Center, Denver, CO.

Correspondence to: Monica Kraft, MD, FCCP, National Jewish Medical and Research Center, B-120, 1400 Jackson St, Denver, CO 80206; e-mail: kraftm@njc.org



Chest. 2003;123(3_suppl):356S. doi:10.1378/chest.123.3_suppl.356S
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Airway remodeling in asthma patients has received a great deal of attention as a process whereby significant structural abnormalities of the bronchial wall occur and may lead to a state of fixed, or irreversible, airway obstruction.1 Among these abnormalities, a thickening of the subepithelial basement membrane has been described repeatedly, and even has been shown in some studies to correlate with bronchial hyperresponsiveness.2 This morphologic change is thought to be due primarily to increased collagen deposition beneath the bronchial epithelium by airway fibroblasts.3

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