The patient was treated for 8 weeks. Her membranes ruptured spontaneously at 35 weeks’ gestation. Terbutaline therapy was added for induction. A healthy infant weighing 2,003 g was delivered vaginally. The newborn was separated from the mother. The placenta was normal on pathology examination. The infant's tuberculin skin test and three nasogastric aspiration cultures were negative for TB. A neurologic examination and electrophysiologic hearing studies of the infant were normal. The baby continued to thrive, and therefore a lumbar puncture was not performed. Following delivery, the patient continued to receive the main drug, capreomycin, 1,000 mg 5 days per week as IV infusion. The drugs that were used to prevent resistance against capreomycin included para-aminosalicylic acid granules, 4,000 mg po three times per day, pyrazinamide, 1.5 g per day, and cycloserine, 500 mg in the morning and 250 mg in the evening with 200 mg vitamin B6 daily. Therapy with ethionamide (500 mg po in the morning and 250 mg in the evening) was added, and levofloxacin therapy was changed to daily therapy with moxifloxacin, 400 mg. The administration of these six drugs was continued because of slow fever resolution, continued weight loss, and sputum smear positivity for > 8 weeks. No adverse effects from the second-line medication were noted. The results of monthly audiometry remained normal, and liver function tests showed only a onefold increase in transaminase levels. Additional consecutive sputum samples were tested at the New York City Department of Health, Bureau of Laboratories, and the tests confirmed the susceptibility pattern of the first specimen. The patient was discharged from the hospital after three consecutive concentrated sputum smears converted to a negative result. Directly observed therapy was continued twice daily 5 days per wk. The total treatment time was scheduled to be 18 months after the documented conversion of monthly sputum cultures to negative for TB. The patient refused directly observed therapy by a public health adviser. After a public health commissioner issued an order for directly observed therapy and a possible detention order was issued, the patient opted to continue observed treatment. The child remained separated from the mother until her sputum cultures converted to negative. Therefore, vaccination with bacillus Calmette-Guerin was not indicated as its effectiveness has not been proven and because bacillus Calmette-Guerin vaccination would interfere with tuberculin skin testing.